CHFR methylation and colon cancer recurrence 1 Association of CHFR Promoter Methylation with Disease Recurrence in Locally Advanced Colon Cancer
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منابع مشابه
Association of CHFR promoter methylation with disease recurrence in locally advanced colon cancer.
PURPOSE This study was designed to determine whether DNA methylation biomarkers are associated with recurrence and survival in colon cancer patients. EXPERIMENTAL DESIGN A retrospective analysis of 82 patients who received curative surgical resection for American Joint Committee on Cancer (AJCC) high-risk stage II or III colon cancer (1999-2007) was conducted. DNA methylation status was quant...
متن کاملImaging, Diagnosis, Prognosis Association of CHFR Promoter Methylation with Disease Recurrence in Locally Advanced Colon Cancer
Purpose: This study was designed to determine whether DNA methylation biomarkers are associated with recurrence and survival in colon cancer patients. Experimental Design: A retrospective analysis of 82 patients who received curative surgical resection for American Joint Committee on Cancer (AJCC) high-risk stage II or III colon cancer (1999–2007) was conducted. DNA methylation status was quant...
متن کاملClinicopathological significance of CHFR promoter methylation in gastric cancer: a meta-analysis
The mitotic checkpoint gene (CHFR) (Checkpoint with Forkhead-associated and Ring finger domains is a G2 phase/mitosis checkpoint and tumor-suppressor gene. Recent studies have reported the relationship of CHFR promoter methylation with clinicopathological significance of gastric cancer. However, the results remain unclear due to small size of sample. We pooled 15 studies including 827 gastric c...
متن کاملMethylation of CHFR sensitizes esophageal squamous cell cancer to docetaxel and paclitaxel
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. Both genetic and epigenetic changes are involved in esophageal carcinogenesis. CHFR methylation has been found frequently in different cancers and is regarded as a marker of taxane sensitivity. CHFR methylation was found in 0% (0/16) of normal mucosa, 2.9% (1/34) of grade I dysplasia, 0% (0/8) of grade I...
متن کاملAberrant methylation of the CHFR gene in digestive tract cancer.
BACKGROUND Recently, aberrant methylation of the CHFR gene associated with gene silencing has been reported in several cancers. The methylation status of the CHFR gene was examined in primary esophageal and gastric carcinomas. MATERIALS AND METHODS The methylation status of the CHFR promoter region and mRNA expression in cancer cell lines were examined first. The methylation status of the CHF...
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تاریخ انتشار 2011